CMA Microdialysis News 2005-2006

2006-12-22
Medel TIP Ltd. has been honoured with the "CMA Distributor of the year 2006" award

"With an impressive drive and committment, Medel TIP has shown a high level of dedication for starting up and driving Microdialysis sales in Turkey. Medel TIP has with a professional approach marketed CMA's products to leading researchers and clinicians through meetings and attendance at large and international congresses. Representatives of CMA have been invited to Turkey at several occasions and worked closely with Medel TIP to attract, educate and help to close clinical and preclinical deals."

2006-11-06
CMA enters the Russian market

CMA is very proud to have signed a distribution agreement with the Biomedical Group based in Moscow. Biomedical Group will assume responsibility for marketing and selling CMA’s clinical products on the Russian and CIS markets. Mr. Andreas Tuvesson, the 2nd Secretary of Economic Affairs, declared the official launch at the Swedish Embassy in Moscow. The event included talks by prominent speakers as Professor Carl-Henrik Nordström of Lund University, Dr. Nikolaenko and Dr. Sergey Patrikov of the leading Sklifosovsky Institute. Local regulatory approvals are expected to be cleared by December 2006.

2006-11-06
New Application note: Storing microdialysis samples.

One of the main characteristics of microdialysis sampling is the small volume involved. At a flow rate of 0.3 μL/min it is theoretically possible to collect only 18 μL during one hour.
Because of the small volumes, the samples are sensitive to evaporation even though they are “sealed ” in the microvials. Furthermore, since the vials may contain different volumes, the effect of evaporation can vary between the samples. Thus, in order to get “quality” results, the samples should be analyzed as soon as possible after collection. Furthermore, chemical and microbiological degradation may also change the sample composition if the samples are stored for a long time.
Samples can be stored in the refrigerator for a few days, but, in general, the colder the samples are kept, the lower the risk of chemical and microbiological degradation...
   Read more
 

2006-10-16
New Refrigerated Fraction Collector

We are happy to launch the new CMA 470 Refrigerated Fraction Collector.
It will be exposed for the first time at the Neurosciense meeting in Atlanta, USA, 15-18 October.

The CMA 470 Refrigerated Fraction Collector is especially designed to collect minute volume fractions typical of microdialysates. It has thermoelectric cooling down to +6 °C and the fractions can be collected in sealed vials. These are important considerations for the prevention of evaporation and chemical degradation. The capacity of the collector is 64 vials of 300 µL each or 40 vials of 2 mL each.

NEW features:
·Equipped with a belonging quadruple assembly the CMA 470 can collect fractions from up to four probes simultaneously.
·Included is also an option with four cannula holders for collecting samples in opened vials directly from the outlet tubing of the probes into the bottom of the vials.
·The CMA 470 Refrigerated Fraction Collector can communicate with other instruments and is equipped with a RS232 and a USB port to make it possible to control the system from a computer.
·It is a stand alone product, no need of a computer for the basic use.
 

2006-10-02
New Syringe Pump launched

We are happy to launch a new two Syringe Pump, CMA 402. It will replace the CMA/102 Microdialysis Pump. The new CMA 402 Syringe Pump has a modern design to match the new family of CMA products. It has some new advanced features in addition to the ones of CMA/102. A 5mL syringe can be used, it has both a USB port and a RS232 computer connection and the direction of the syringe flow can easily be reversed individually.
The new pump is available in two versions.

2006-09-20
ISCUS receives Brazilian approval

The regulatory body of Brazil, Anvisa, has approved the ISCUS Clinical Microdialysis Analyzer for use in neuro intensive care.
  product note>> 

2006-09-13
CMA receives research grant

CMA has a received a 0,5 million SEK research grant from Vinnova, The Swedish Governmental Agency for Innovation Systems.
 

2006-09-07
CMA launches the new CMA 63 Microdialysis Catheter

The CMA 63 Microdialysis Catheter allows for continuous monitoring of tissue metabolism in adipose tissue, resting skeletal muscle or in hepatic tissue during open surgery. Two different sizes of membrane and shaft length make the catheter suitable for many different applications. The CMA 63 Catheter is optimized for to detect ischemia in free flaps, measure chemistry changes in hepatic tissue and for metabolic studies in muscle or adipose tissue. The catheter is easily introduced into the tissue with a splitable introducer.
For more info see
  product note >>

2006-06-01
Microdialysis now on DVD!

At a Microdialysis Institute course held recently we filmed the main lectures in order to make an educational tool appealing to various categories of doctors, such as; potential course participants; earlier participants as a brush up and last but not least a comprehensive educational material for self learning. Presenters are Urban Ungerstedt (A) Karolinska Institute Stockholm and Carl-Henrik Nordström (B), University Hospital of Lund.

A: Basic Clinical Microdialysis- an overview of the MD technique Principles and application; The hollow fibre; Uptake and release; Recovery; Osmosis; Animal cf. man; Sub-cutaneous implantation; Why monitor organ chemistry; MD Instruments; Ischemia; Cell damage; Normal values: Clinical applications; A window of opportunities; FAQ

B: Microdialysis in Neuro Intensive Care
Monitoring in Neuro intensive care; Clinical Microdialysis; Base line Values; Glucose and Lactate/Pyruvate ratio; Glycerol and Glutamate; Biochemical alterations in fatal head injuries; Catheter placement; Global vs local monitoring SAH; Global vs local monitoring severe neuro trauma; Severe neuro trauma; Treatment of increased ICP; The Lund Concept; Movie: Insertion of CMA 70 catheter; Large primary ICH; Large MCA infarcts; Hypothermia; Microdialysis - ready for bedside?
 

2006-05-04
CMA announces today that ISCUS Clinical Microdialysis Analyzer has received FDA 510(k) clearance.

"This is a major milestone for CMA and breakthrough for Microdialysis as a neuro-monitoring tool. I am confident that ISCUS and CMA’s Cerebral Tissue Monitoring System will greatly help physicians to treat brain injured patients by providing a unique bedside tool to monitor changes in brain chemistry.” says Philip Siberg, Chief Executive Officer of CMA Microdialysis AB.
 

2006-05-02
The CMA 61 Hepatic Microdialysis Catheter has now entered the market with an optimized new design!

2006-04-20
Microdialysis in Clinical Practice: Monitoring Intraoral Free Flaps.

Jyranki J , Suominen S , Vuola J , Back L.
Our results indicate that Microdialysis is safe for the patient and the flap. It can reliably detect flap ischemia at an early stage. This is especially useful in buried flaps when clinical monitoring is difficult. Microdialysis may also reduce the patient discomfort caused by repeated clinical examination of the flap

2006-03-13
The new CMA 70 Bolt Catheter

The new CMA 70 Bolt Catheter comes with a 16,5 mm stainless steel re-inforced section located inside the shaft, which allows for full tightening of the bolt compression screw. This unique feature provides a decreased risk of stop in flow when tightening the bolt compression screw. The catheter is compatible with Integra’s IM2 and IM 3 Bolt systems and is available now!
 
   See product note>>

2006-03-02
CMA-Pronexus partnership

There is now comprehensive info available on the partnership with Pronexus and what CMA together with Pronexus can offer customers regarding in vivo Microdialysis contract research services.
   See PDF file>>

2006-02-07
Microdialysis detects postoperative perfusion failure in microvascular flaps.

Microdialysis is a clinically feasible and sensitive monitoring method for all kinds of microvascular flaps, especially for those in which clinical observation is difficult or impossible. The performance of the analysis is easy and can be done by even less experienced nursing staff working in institutes with a low frequency of microsurgery... No flap was lost due to a delay in the diagnosis of secondary ischemia, if online MD monitoring was available...

Microdialysis detects postoperative perfusion failure in microvascular flaps.
Lena Setälä etc, Journal of Recontructive Surgery, nr, 2006
read more>>

 
 
2006-02-01 CMA annouces grant to support higher biomedical education

For more info in Swedish, please see    Stipendieutlysning.pdf

2006-01-20
The Royal Academy of Science has awarded Professor Urban Ungerstedt.

The Royal Academy of Science has awarded Professor Urban Ungerstedt, Karolinska Institute, Sweden, the prize of Hilda and Alfred Eriksson, for his Development of the Microdialysis method. The prize was instituted in 1969 to "reward scientific efforts that may relieve illnesses both in human beings and animals." Professor Ungerstedt gets the prize together with Professor Leif Wide, Uppsala, Sweden.

2006-01-18
CMA NEWSLETTER

Send for our Newsletter to get updated on what is happening at CMA.
CMA sends regularly a Newsletter to customers to inform about product news-changes, Microdialysis courses, conferences, recent publications both in research and the clinical applications etc Now we want to make it possible for everyone to take part of our news. Please register and you will get our next CMA Newsletter to your e-mail box. Register by sending an email to: cma@microdialysis.se

2006-01-10
News from the Microdialysis Focus Group of the AAPS (American Association of Pharmaceutical Science).

The Microdialysis Focus Group of the AAPS aims to be a stimulant and vehicle for the exchange of information and discussions on the Microdialysis technique with respect to its important current applications and future potentials in quantitative drug research and development.

Within the last decades it has become clear that in vivo Microdialysis is of unique value in quantitative pharmacological research. It is the only in vivo technique that is able to provide temporal information on local free concentrations of drugs and metabolites in the extracellular space at specific sites in the body. Thus, quantitative in vivo Microdialysis studies have provided new information on drug delivery to, for example, the CNS and subcutaneous sites, on distribution to the liver, lung, muscle, adipose and other target tissues, as well as on the characterization of blood levels of drug and metabolites. The microdialysis technique is therefore closely connected to the research fields of drug delivery, drug metabolism, pharmacokinetics, and pharmacodynamics, while the state-of-art analytical technologies are needed, and expansion of Microdialysis applications will follow progress in analytical technologies.

The Membership of the Microdialysis Focus Group is open to any AAPS member who has an interest in microdialysis, and in time, the Members have exceeded the number of 250.
read more: www.aapspharmaceutica.com/inside/focus_groups/Microdial/index.asp

2005-12-29
CMA Microdialysis and Pronexus form a strategic partnership.

CMA Microdialysis and Pronexus form a strategic partnership to offer Microdialysis contract research services. Pronexus Analytical is a contract research organization offering services to pharmaceutical companies and research institutions active within the therapeutic area of diseases affecting the central nervous system. Through the partnership, CMA and Pronexus can enable in vivo Microdialysis and allied analytical techniques to accelerate the process of drug discovery, particularly in its late phase strengthening the functional validation of candidate drugs.

2005-12-19
Distribution agreement with Alfatech S.p.A. in Italy

CMA is proud to have signed a new distribution agreement with Alfatech S.p.A. in Italy. Alfatech is a leading company active in the scientific research sector and will exclusively distribute CMA's basic research products in Italy.

2005-12-15
Expansion into Africa

The Microdialysis technique continues its global expansion into Africa as CMA sells its first CMA 600 Bedside Analyzer to Tunisia

2005-12-07
Phymep has been awarded "CMA Distributor of the year 2005" award.

The jurys statement: “With long and great performance, Phymep has for over 15 years distributed CMA’s products in France. Phymep has an excellent market position, a dedicated team and impressive local market knowledge. Gerard Montagne and Jean-Pierre Printemps have with great loyalty managed to successfully grow the Microdialysis business in France and built a long-term relationship to become one of CMA’s best performing distributors.” Congratulations Phymep!

2005-12-05
CMA sells the first CMA600 Microdialysis Bedside Analyzer to Sarajevo, Bosnia and Herzegovina.

2005-12-01
CMA launches a new Linear Probe.

The new CMA 30 Linear Microdialysis Probe is the ideal product for exploring peripheral tissues such as skin, muscle, heart, adipose tissue, liver, eye and other organs as well as spinal cord and tumours. The probe comes with a Cuprophane membrane with a cut-off of 6.000 Daltons.

2005-12-01
CMA launches the CMA12 Elite and CMA 20 Elite Microdialysis Probes with a PAES-membrane.

The new membrane with 20.000 Dalton cut-off, offers excellent recovery, is sterilizable by EtO, has a fast start up procedure and is reduced in price.

2005-11-29
A new clinical and preclinical distribution agreement with Medel Tip Ltd
 
CMA has signed a new clinical and preclinical distribution agreement with Medel Tip Ltd. Medel Tip, based in Ankara and Istanbul, is focused on intensive care products and will assume the exclusive responsibility for CMA's products Turkey.

2005-11-21
CMA is proud to have signed a new clinical distribution contract with the Marifarma Group in Italy.

Mr. Andrea Laurenzi, formerly Area Sales Manager for CMA in Italy, will manage the Microdialysis division of Marifarma. The Marinelli Group, which includes Marifarma, is one of the leading companies in Italy operating in the commercialization of medical technologies and pharmaceutical products.

2005-11-05
New multicenter study launched. Dep. of Gastrointestinal Surgery, Odense University Hospital, Denmark has started a multicenter study on patients with low cancer recti.

Hospitals included in the study are Slagelse, Svendborg, Vejle and Odense. The study is a retrospective study and the aim with the study is to determine if Microdialysis can detect an anastomosis leakage before any other clinical signs.

Approximately 120 patients are planned to be included in the study the first year. A medical student is hired to work full time only to coordinate the logistics and analyse samples on the CMA600 Microdialysis Analyzer
Aalborg University Hospital in Denmark is also starting a retrospective gastrointestinal study. This study will combine clinical and animal studies.

2005-11-04
Urban Ungerstedt to key note speak at the AAPS meeting

Professor Urban Ungerstedt to key note speak at the AAPS meeting on Microdialysis, hosted by FDA, in Nashville, Tennessee
more info about the meeting >>

2005-10-29
Urban Ungerstedt at the JAAM in Tokyo

Professor Urban Ungerstedt to lecture on Microdialysis at the 33rd Annual Meeting of the JAAM in Tokyo, Japan.

2005-09-29
New clinical distribution agreement with Rentaltec in Brazil

CMA signs new clinical distribution agreement with Rentaltec in Brazil. Renaltec is a leading player based in Rio.

2005-08-05
CMA sells its first ISCUS Microdialysis Analyzer to Russia.

2005-06-15
CMA receives additional funding of $5,5 M from existing investors.

This will enable continued efforts to develop unique and leading Microdialysis products for existing and new applications.

2005-06-10
The CMA600 analyser has now been approved by local authorities for sale in the Federal Republic of China.

Local sales and marketing is exclusivly handled by CMA’s distributor Bioway LLC

2005-04-20
New Board Members

New Board Members appointed at Annual Shareholders Meeting. Dr. Med Sc. Magnus Nilsson, CEO of Vitrolife, and Jeff Bork, CEO of Biotage. Both gentlemen will bring extensive experience from the Bio- and Med Tech industry.

2005-04-12
Philip Siberg appointed new CEO of CMA Microdialysis AB .

Philip Siberg is a member of the board and previously employed at Skanditek, a listed private equity company and the largest shareholder in CMA.