Microdialysis Applications

Overview

Microdialysis is used successfully to address various issues in many different clinical fields, such as monitoring for early detection of secondary brain injuries, flap thrombosis, myocardial ischemia and continuous glucose monitoring. It is also used in Clinical research applications, such as early indication of transplant rejections and anastomosis leakage.

In clinical pharmacology microdialysis is used as a tool to measure target site concentrations of antibiotics or anticancer drugs in different tissues and organs and to subsequently relate target site PK to PD. Leading university hospitals around the globe use CMA’s clinical solutions for continuous monitoring of specific tissues and systemically in blood.

As global drug development costs continue to escalate, partially because of the high attrition rate of development candidates, there is increasing pressure to improve the predictability of clinical outcomes from preclinical studies. By understanding the exposure in the appropriate biophase, as well as the effect of a drug candidate at the site of action, selection and optimal doses of the best compound can be improved.

Microdialysis is a practical and data-rich in vivo method, which is extremely useful tool to investigate the PK/PD profiles of drug candidates. CMA’s basic research solutions are used by leading pharmaceutical companies in the drug discovery process to assess drug concentrations at the site of drug delivery.

Our focus application areas

Reconstructive Surgery

A reliable and cost-effective tool that controls the success of the flap transfer. It can identify ischemia or a thrombosis and
is preferable used on deep buried flaps.

Cardiac Monitoring

A novel diagnostic system for cardiac monitoring which provides continuous measurements of metabolic markers inside the Coronary Sinus and is used for early detection of post operative myocardial ischemia.

Continous Glucose Monitoring

Glucose control is taken to the next step by our continous glucose monitoring system that provides continuous measurement of blood glucose in critically ill patients. Continuous measurement of blood lactate is also available.

Neuro Monitoring

A unique and effective tool that offers an early indication of secondary injuries and makes it possible to guide and evaluate therapy after Traumatic brain injury and Subarachnoid Hemorrhage.

Clinical Research

A unique method for monitoring local tissue chemistry in different tissues and organs after surgery with the potential to identify secondary complications and guide therapy. It can also be used to investigate drug delivery into local tissues
and organs.

Basic Research

A unique method for Neuroscience and quantitative pharmacological research. It is the only in vivo technique that can provide information on local free concentrations of drugs and metabolites in the extracellular space at specific sites in
the body.

Automated Blood Sampling

Automatic Blood Sampling (ABS) is a technique for automatically drawing blood from freely moving undisturbed animals. The DiLab AccuSampler® enables routine collection of small sample sizes at frequent minute intervals. The technique is predominantly used in preclinical trials. Common areas of use are Pharmacokinetics, Pharmacodynamics, ADME, Toxicology, Safety Pharmacology and Biomarker research. Since 2010, DiLab® is part of the CMA group.